Lee HM, Le TV, Lopez VA, Wong ND |
Association of C-reactive protein with reduced forced vital capacity in a nonsmoking U.S. population with metabolic syndrome and diabetes |
Diabetes Care 2008 Oct; 31(10): 2000-2 |
OBJECTIVE: |
RESEARCH DESIGN AND METHODS: We examined the association of MetS/diabetes and CRP (normal less than or = 3 mg/l, high greater than 3 mg/l) with predicted FVC in 4,272 nonsmoking U.S. adults aged 18-79 years without lung disease in the Third National Health and Nutrition Examination Survey. Logistic regression examined odds of FVC less than 80% by CRP and MetS/diabetes. |
RESULTS: Mean FVC in individuals with MetS and high CRP (95.7%) and those with diabetes and high CRP (93.7%) was lower than in those with no MetS/diabetes and normal CRP (101.7%) (P < 0.01) and was lower in those with MetS and high CRP (95.7%) than in those with MetS and normal CRP (98.5%) (P < 0.01). The odds ratio (95% CI) of FVC less than 80% was highest in individuals with MetS and high CRP (odds ratio 4.26 [95% CI 2.08-8.73], P < 0.01) compared with those with no MetS/diabetes and normal CRP. |
CONCLUSIONS: Elevated CRP is associated with lower FVC in people with MetS. |